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Article

PepGen: conditional generation of peptides for MHC binding.

Bioinformatics (Oxford, England) - 1 Aug 2026

Korpela Dani, Dumitrescu Alexandru, Stražar Martin, Li Rui, Xavier Ramnik J, Graham Daniel B, Lähdesmäki Harri

Abstract excerpt

MOTIVATION: Peptide-MHC II binding drives adaptive immunity, yet discovery of novel binder peptides remains challenging due to open binding grooves of MHC-II that accommodate variable-length peptides. While discriminative models perform well, they are unfeasible for generation via enumeration due to vast peptide space (2013≈8×1016 for peptides of length 13 amino acids). Generative AI approaches could accelerate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42635241
DOI: 10.1093/bioinformatics/btag464
PMCID: PMC13501301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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