p-IgGen: A Paired Antibody Generative Language Model

Abstract excerpt

<h4>Summary</h4> A key challenge in antibody drug discovery is designing novel sequences that are free from developability issues - such as aggregation, polyspecificity, poor expression, or low solubility. Here, we present p-IgGen, a protein language model for paired heavylight chain antibody generation. The model generates diverse, antibody-like sequences with pairing properties found in natural antibodies. We a...

Topics

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• Amino Acid Sequence
• Antibodies
• Computational Biology
• Germ-Line Mutation
• Monoclonal and Polyclonal Antibodies Research
• Mutation
• Protein purification and stability
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

59f8e3d2-06d9-5751-ad55-bd11802b5779

DOI

10.1101/2024.08.06.606780