Article

ProChoreo: <i>de novo</i> Binder Design from Conformational Ensembles with Generative Deep Learning

2026-01-26

Abstract excerpt

Deep learning has transformed protein structure prediction and de novo protein design; however, most existing frameworks operate on a single static conformation and underutilize the conformational heterogeneity that governs protein binding and function. We introduce ProChoreo, a generalizable framework for de novo binder design that explicitly incorporates conformational ensembles. ProChoreo is pretrained with m...

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Literature Corpus work: bd81662a-04b0-506b-a98f-1f4c4e3e123b
DOI: 10.64898/2026.01.23.701298

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