Article

Rebuilding the Antibiotic Pipeline with Guided Generative Models

2026-01-16

Abstract excerpt

The antibiotic pipeline has stalled: most recent approvals reflect incremental modifications of existing scaffolds, while antimicrobial resistance continues to outpace discovery. Antimicrobial peptides (AMPs) offer a compelling alternative because of rapid, multi-modal activity, but clinical translation has been limited by toxicity, serum instability, and the prohibitive cost of synthesizing and testing large libr...

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Literature Corpus work: 20134723-c0c2-5899-ac7a-067023091d07
DOI: 10.20944/preprints202601.1230.v1

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