Article

PHbinder and PSGM: A Cascaded Framework for Epitope Prediction and HLA-I Allele Identification

2025-06-27

Abstract excerpt

The presentation of antigens by Human Leukocyte Antigen class I (HLA-I) molecules is a cornerstone of adaptive immunity. Although existing prediction tools such as NetMHCpan and MHCflurry exhibit high accuracy in predicting binding affinity between peptides and specific HLA-I alleles, they are constrained to a preset set of alleles. Consequently, they can neither directly determine whether a peptide is an epitope...

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Literature Corpus work: 9cf699f2-8823-58df-aa51-c5a7cf8c232a
DOI: 10.1101/2025.06.25.661428

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