Article
Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.
Immunity - 1 Jun 2001
Horcher M, Souabni A, Busslinger M
Abstract excerpt
The B lineage commitment factor Pax5 (BSAP) is expressed throughout B cell development. To investigate its late function, we generated a mouse strain carrying a floxed Pax5 allele that was conditionally inactivated by CD19-cre or Mx-cre expression. Pax5 deletion resulted in the preferential loss of mature B cells, inefficient lymphoblast formation, and reduced serum IgG levels. Mature B cells radically changed...
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