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PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia

5 Aug 2019

Abstract excerpt

One of the most frequently mutated proteins in human B-lineage leukemia is the transcription factor PAX5. These mutations often result in partial rather than complete loss of function of the transcription factor. While the functional dose of PAX5 has a clear connection to human malignancy, there is limited evidence for that heterozygote loss of PAX5 have a dramatic effect on the development and function of B-cell...

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PMID: 31381561
DOI: 10.1371/journal.pgen.1008280

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