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Article

PAX5 alterations in B-cell acute lymphoblastic leukemia

25 Oct 2022

Abstract excerpt

PAX5, a master regulator of B cell development and maintenance, is one of the most common targets of genetic alterations in B-cell acute lymphoblastic leukemia (B-ALL). PAX5 alterations consist of copy number variations (whole gene, partial, or intragenic), translocations, and point mutations, with distinct distribution across B-ALL subtypes. The multifaceted functional impacts such as haploinsufficiency and...

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PMID: 36387144
DOI: 10.3389/fonc.2022.1023606

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