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Article

The regulation of the B‐cell gene expression programme by Pax5

13 Nov 2007

Abstract excerpt

The activity of the transcription factor paired box gene 5 (Pax5) is essential for many aspects of B lymphopoiesis including the initial commitment to the lineage, immunoglobulin rearrangement, pre-B cell receptor signalling and maintaining cell identity in mature B cells. Deregulated or reduced Pax5 activity has also been implicated in B-cell malignancies both in human disease and mouse models. Candidate gene...

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PMID: 17998914
DOI: 10.1038/sj.icb.7100134

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