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Article

Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.

The Journal of clinical investigation - 1 Sept 2015

Duque-Afonso Jesús, Feng Jue, Scherer Florian, Lin Chiou-Hong, Wong Stephen H K, Wang Zhong, Iwasaki Masayuki, Cleary Michael L

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer; however, its genetic diversity limits investigation into the molecular pathogenesis of disease and development of therapeutic strategies. Here, we engineered mice that conditionally express the E2A-PBX1 fusion oncogene, which results from chromosomal translocation t(1;19) and is present in 5% to 7% of pediatric ALL cases. The incidence of...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26301816
DOI: 10.1172/JCI81158
PMCID: PMC4588292

Genes

PBX1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.PMID 26301816Read ↗

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