Article

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia

2020-11-27

Abstract excerpt

The transcription factors EBF1 and PAX5 are frequently mutated in B cell acute lymphoblastic leukemia (B-ALL). We demonstrate that Pax5 +/- x Ebf1 +/- compound heterozygous mice develop highly penetrant leukemia. Similar results were seen in Pax5 +/- x Ikzf1 +/- and Ebf1 +/- x Ikzf1 +/- mice for B-ALL, or in Tcf7 +/- x Ikzf1 +/- mice for T cell leukemia. To identify genetic defects that cooperate with Pax5 an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a9dd03f1-c084-5ec7-b6ea-2d39fecdedfc
DOI: 10.1101/2020.11.25.398966

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemiaDOI 10.1101/2020.11.25.398966Read

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia.Semantic proximity Read

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.Semantic proximity Read

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemiaSemantic proximity Read

B-lineage transcription factors and cooperating gene lesions required for leukemia development.Semantic proximity Read

PAX5 is part of a functional transcription factor network targeted in lymphoid leukemiaSemantic proximity Read

PAX5 alterations in B-cell acute lymphoblastic leukemiaSemantic proximity Read

Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia.Semantic proximity Read

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.Semantic proximity Read

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in miceSemantic proximity Read

PAX5 fusion genes in acute lymphoblastic leukemia: A literature review.Semantic proximity Read

Signaling Proteins and Transcription Factors in Normal and Malignant Early B Cell DevelopmentSemantic proximity Read

Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.Semantic proximity Read