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Article

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemia

12 Aug 2015

Abstract excerpt

BACKGROUND: B-cell precursor acute lymphoblastic leukemia (B-ALL) is amongst the leading causes of childhood cancer-related mortality. Its most common chromosomal aberration is the ETV6-RUNX1 fusion gene, with ~25% of ETV6-RUNX1 patients also carrying PAX5 alterations. METHODS: We have recreated this mutation background by inter-crossing Etv6-RUNX1 (Etv6 (RUNX1-SB)) and Pax5(+/-) mice and performed an in vivo...

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PMID: 26269126
DOI: 10.1186/s12885-015-1586-1

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