Article
GEMMs addressing Pax5 loss-of-function in childhood pB-ALL.
European journal of medical genetics - 1 Mar 2016
Auer Franziska, Ingenhag Deborah, Bhatia Sanil, Enczmann Jürgen, Cobaleda Cesar, Sanchez-Garcia Isidro, Borkhardt Arndt, Hauer Julia
Abstract excerpt
Germline mutations in transcription factors, which are implicated in hematopoiesis in general or specifically in B-cell differentiation have recently been described to confer an inherited risk to pB-ALL with often reduced penetrance. Predicting leukemia development, therapy response and long term follow up of mutation carriers is challenging because experience from large patient cohorts and their long term follow...
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