Article
Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia.
Oncogene - 1 Oct 2021
Heltemes-Harris Lynn M, Hubbard Gregory K, LaRue Rebecca S, Munro Sarah A, Yang Rendong, Henzler Christine M, Starr Timothy K, Sarver Aaron L, Kornblau Steven M, Farrar Michael A
Abstract excerpt
The transcription factors PAX5, IKZF1, and EBF1 are frequently mutated in B cell acute lymphoblastic leukemia (B-ALL). We demonstrate that compound heterozygous loss of multiple genes critical for B and T cell development drives transformation, including Pax5+/-xEbf1+/-, Pax5+/-xIkzf1+/-, and Ebf1+/-xIkzf1+/- mice for B-ALL, or Tcf7+/-xIkzf1+/- mice for T-ALL. To identify genetic defects that cooperate with Pax5...
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