Article
Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus.
Blood - 1 Jan 2007
Souabni Abdallah, Jochum Wolfram, Busslinger Meinrad
Abstract excerpt
Four of 9 PAX transcription factor genes have been associated with chromosomal translocations in human tumors, although their oncogenic potential has not yet been demonstrated in transgenic mouse models. The B-lymphoidPAX5 gene participates in the generation of the t(9;14)(p13;q32) translocation in germinal center B cells, which leads to deregulated PAX5 expression under the control of the immunoglobulin...
Topics
- Alleles
- Animals
- B-Lymphocytes
- Bone Marrow Transplantation
- Cell Differentiation
- Cell Lineage
- Cell Transformation, Neoplastic
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 9
- Dendritic Cells
- Embryonal Carcinoma Stem Cells
- Gene Expression Regulation, Neoplastic
- Humans