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Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies

21 Apr 2023

Abstract excerpt

Human monoclonal antibodies (mAbs) against the central repeat and junction domain of Plasmodium falciparum circumsporozoite protein (PfCSP) have been studied extensively to guide malaria vaccine design compared to antibodies against the PfCSP C terminus. Here, we describe the molecular characteristics and protective potential of 73 germline and mutated human mAbs against the highly immunogenic PfCSP C-terminal...

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PMID: 37082831
DOI: 10.15252/emmm.202317454

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