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Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination

2024-11-11

Abstract excerpt

Vaccination with radiation-attenuated sporozoites (RAS) can provide highly effective protection against malaria in both humans and mice. To extend understanding of malaria immunity and inform the development of future vaccines, we studied the protective response elicited by this vaccine in C57BL/6 mice. We reveal that successive doses of Plasmodium berghei RAS favour the generation of liver CD8 + tissue-resident...

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Literature Corpus work
affe95c4-ecce-56b1-ac07-8be7a7a1f064
DOI
10.1101/2024.11.08.622604
Open publication

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Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccinationDOI 10.1101/2024.11.08.622604
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