Article
A Tonic Signaling Code Predicts CAR-T Cell Efficacy in Diffuse Midline Glioma
2025-10-01
Abstract excerpt
<h4>Summary</h4> Diffuse midline glioma (DIPG/DMG) is a uniformly fatal pediatric brain tumor with no effective cure. Although CAR T-cell therapy shows promise, clinical outcomes remain inconsistent due to limited persistence and premature exhaustion. Reliable predictive biomarkers are lacking, and proposed exhaustion or stemness markers provide limited utility. Here, we systematically compare multiple CAR-T cons...
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Identifiers and source
- Literature Corpus work
- 2f2c6505-fadb-5453-bbea-0413dda9c663
- DOI
- 10.1101/2025.09.29.679095