Article

<i>De novo</i> H3.3K27M-altered Diffuse Midline Glioma in human brainstem organoids to dissect GD2 CAR T cell function

2025-12-16

Abstract excerpt

Diffuse midline glioma (DMG) is a rare yet highly aggressive paediatric cancer primarily arising in the pontine region of the brainstem, necessitating the development of scalable patient-representative models for treatment advance 1,2 . Here, we developed an FGF4-driven human brainstem organoid model, with high representation of pontine glial lineages. By genetically engineering de novo H3.3K27M-altered DMG, we...

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Literature Corpus work: cd265304-1ceb-5be8-b752-07068263987f
DOI: 10.64898/2025.12.15.694282

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