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Article

Single-Cell Transcriptomics Reveals the Heterogeneity of the Immune Landscape of IDH-Wild-Type High-Grade Gliomas.

Cancer immunology research - 2 Feb 2024

Ran Xiaojuan, Zheng Jian, Chen Linchao, Xia Zhen, Wang Yin, Sun Chengfang, Guo Chen, Lin Peng, Liu Fuyi, Wang Chun, Zhou Jianguo, Sun Chongran, Liu Qichang, Ma Jianzhu, Qin Zhiyong, Zhu Xiangdong, Xie Qi

Abstract excerpt

Isocitrate dehydrogenase (IDH)-wild-type (WT) high-grade gliomas, especially glioblastomas, are highly aggressive and have an immunosuppressive tumor microenvironment. Although tumor-infiltrating immune cells are known to play a critical role in glioma genesis, their heterogeneity and intercellular interactions remain poorly understood. In this study, we constructed a single-cell transcriptome landscape of immune...

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Identifiers

PMID: 38091354
DOI: 10.1158/2326-6066.CIR-23-0211
PMCID: PMC10835213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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