GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas.

doi:10.1038/s41586-022-04489-4

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Article

GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas.

Nature - 1 Mar 2022

Majzner Robbie G, Ramakrishna Sneha, Yeom Kristen W, Patel Shabnum, Chinnasamy Harshini, Schultz Liora M, Richards Rebecca M, Jiang Li, Barsan Valentin, Mancusi Rebecca, Geraghty Anna C, Good Zinaida, Mochizuki Aaron Y, Gillespie Shawn M, Toland Angus Martin Shaw, Mahdi Jasia, Reschke Agnes, Nie Esther H, Chau Isabelle J, Rotiroti Maria Caterina, Mount Christopher W, Baggott Christina, Mavroukakis Sharon, Egeler Emily, Moon Jennifer, Erickson Courtney, Green Sean, Kunicki Michael, Fujimoto Michelle, Ehlinger Zach, Reynolds Warren, Kurra Sreevidya, Warren Katherine E, Prabhu Snehit, Vogel Hannes, Rasmussen Lindsey, Cornell Timothy T, Partap Sonia, Fisher Paul G, Campen Cynthia J, Filbin Mariella G, Grant Gerald, Sahaf Bita, Davis Kara L, Feldman Steven A, Mackall Crystal L, Monje Michelle

Abstract excerpt

Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal paediatric tumours of the central nervous system1. We have previously shown that the disialoganglioside GD2 is highly expressed on H3K27M-mutated glioma cells and have demonstrated promising preclinical efficacy of GD2-directed chimeric antigen receptor (CAR) T cells2, providing the rationale for...

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PMID: 35130560
DOI: 10.1038/s41586-022-04489-4
PMCID: PMC8967714

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