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Article

Pediatric diffuse midline glioma: Understanding the mechanisms and assessing the next generation of personalized therapeutics

1 Jan 2023

Abstract excerpt

Abstract Diffuse midline glioma (DMG) is a pediatric cancer that originates in the midline structures of the brain. Prognosis of DMG patients remains poor due to the infiltrative nature of these tumors and the protection they receive from systemically delivered therapeutics via an intact blood–brain barrier (BBB), making treatment difficult. While the cell of origin remains disputed, it is believed to reside in...

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PMID: 37152806
DOI: 10.1093/noajnl/vdad040

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