Article
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location.
Nature genetics - 1 Dec 2022
Liu Ilon, Jiang Li, Samuelsson Erik R, Marco Salas Sergio, Beck Alexander, Hack Olivia A, Jeong Daeun, Shaw McKenzie L, Englinger Bernhard, LaBelle Jenna, Mire Hafsa M, Madlener Sibylle, Mayr Lisa, Quezada Michael A, Trissal Maria, Panditharatna Eshini, Ernst Kati J, Vogelzang Jayne, Gatesman Taylor A, Halbert Matthew E, Palova Hana, Pokorna Petra, Sterba Jaroslav, Slaby Ondrej, Geyeregger Rene, Diaz Aaron, Findlay Izac J, Dun Matthew D, Resnick Adam, Suvà Mario L, Jones David T W, Agnihotri Sameer, Svedlund Jessica, Koschmann Carl, Haberler Christine, Czech Thomas, Slavc Irene, Cotter Jennifer A, Ligon Keith L, Alexandrescu Sanda, Yung W K Alfred, Arrillaga-Romany Isabel, Gojo Johannes, Monje Michelle, Nilsson Mats, Filbin Mariella G
Abstract excerpt
Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in diffuse midline gliomas (DMGs) of the childhood pons but are also increasingly recognized in adults. Their potential heterogeneity at different ages and midline locations is vastly understudied. Here, through dissecting the single-cell transcriptomic, epigenomic and spatial architectures of a comprehensive cohort of patient H3-K27M...
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