Article

APOE genotype-dependent differences in human astrocytic energy metabolism

2025-04-02

Abstract excerpt

The main genetic risk factor for Alzheimer’s disease (AD) is the presence of the apolipoprotein E4 ( APOE4 ) allele. While APOE4 increases the risk of developing AD, the APOE2 allele is protective and APOE3 is risk-neutral. In the brain, APOE is primarily expressed by astrocytes and plays a key role in various processes including cholesterol and lipid transport, neuronal growth, synaptic plasticity, immune res...

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Literature Corpus work: 7950fa8a-9aa5-5993-9612-89be53f291d4
DOI: 10.1101/2025.03.31.646283

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