Article

Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse Brain

2024-08-13

Abstract excerpt

<h4>ABSTRACT</h4> Apolipoprotein E (ApoE) polymorphisms modify the risk of neurodegenerative disease with the ApoE4 isoform increasing and ApoE2 isoform decreasing risk relative to the ‘wild-type control’ ApoE3 isoform. To elucidate how ApoE isoforms alter the proteome, we measured relative protein abundance and turnover in transgenic mice expressing a human ApoE gene (isoform 2, 3, or 4). This data provides insi...

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Literature Corpus work: 958e94a3-52b5-5c3b-bf0e-15460143d7f0
DOI: 10.1101/2024.08.13.607719

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