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Article

APOE genotype-dependent differences in human astrocytic energy metabolism

1 Sept 2025

Abstract excerpt

Introduction The main genetic risk factor for Alzheimer’s disease (AD) is the presence of the apolipoprotein E4 ( APOE4 ) allele. While APOE4 increases the risk of developing AD, the APOE2 allele is protective and APOE3 is risk-neutral. In the brain, APOE is primarily expressed by astrocytes and plays a key role in various processes including cholesterol and lipid transport, neuronal growth, synaptic plasticity,...

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PMID: 40958776
DOI: 10.3389/fncel.2025.1603657

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