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Article

Apolipoprotein E in lipid metabolism and neurodegenerative disease.

Trends in endocrinology and metabolism: TEM - 1 Aug 2023

Yang Linda G, March Zachary M, Stephenson Roxan A, Narayan Priyanka S

Abstract excerpt

Dysregulation of lipid metabolism has emerged as a central component of many neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E (APOE), modulate risk and resilience in several neurodegenerative diseases including late-onset Alzheimer's disease (LOAD). Allelic variants of the gene, APOE, alter the lipid metabolism of cells and tissues and have been broadly associated with several...

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Identifiers

PMID: 37357100
DOI: 10.1016/j.tem.2023.05.002
PMCID: PMC10365028

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