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Article

APOE genotype dictates lipidomic signatures in primary human hepatocytes.

Journal of lipid research - 1 Feb 2024

Almeida Francisco C, Patra Kalicharan, Giannisis Andreas, Niesnerova Anezka, Nandakumar Renu, Ellis Ewa, Oliveira Tiago Gil, Nielsen Henrietta M

Abstract excerpt

Apolipoprotein E (APOE) genetic variants are most notably known for their divergent impact on the risk of developing Alzheimer's disease. While APOE genotype has been consistently shown to modulate lipid metabolism in a variety of cellular contexts, the effect of APOE alleles on the lipidome in hepatocytes is unknown. In this study, we investigated the contribution of APOE alleles to lipidomic profiles of...

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Identifiers

PMID: 38216055
DOI: 10.1016/j.jlr.2024.100498
PMCID: PMC10875595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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