Article
Active Alu retrotransposons in the human genome.
Genome research - 1 Dec 2008
Bennett E Andrew, Keller Heiko, Mills Ryan E, Schmidt Steffen, Moran John V, Weichenrieder Oliver, Devine Scott E
Abstract excerpt
Alu retrotransposons evolved from 7SL RNA approximately 65 million years ago and underwent several rounds of massive expansion in primate genomes. Consequently, the human genome currently harbors 1.1 million Alu copies. Some of these copies remain actively mobile and continue to produce both genetic variation and diseases by "jumping" to new genomic locations. However, it is unclear how many active Alu copies...
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