Article
A systematic analysis of LINE-1 endonuclease-dependent retrotranspositional events causing human genetic disease.
Human genetics - 1 Sept 2005
Chen Jian-Min, Stenson Peter D, Cooper David N, Férec Claude
Abstract excerpt
Diverse long interspersed element-1 (LINE-1 or L1)-dependent mutational mechanisms have been extensively studied with respect to L1 and Alu elements engineered for retrotransposition in cultured cells and/or in genome-wide analyses. To what extent the in vitro studies can be held to accurately reflect in vivo events in the human genome, however, remains to be clarified. We have attempted to address this question...
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