Genomic deletions created upon LINE-1 retrotransposition.

doi:10.1016/s0092-8674(02)00828-0

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Article

Genomic deletions created upon LINE-1 retrotransposition.

Cell - 9 Aug 2002

Gilbert Nicolas, Lutz-Prigge Sheila, Moran John V

Abstract excerpt

LINE-1 (L1) retrotransposition continues to impact the human genome, yet little is known about how L1 integrates into DNA. Here, we developed a plasmid-based rescue system and have used it to recover 37 new L1 retrotransposition events from cultured human cells. Sequencing of the insertions revealed the usual L1 structural hallmarks; however, in four instances, retrotransposition generated large target site...

Topics

Base Sequence
Cloning, Molecular
DNA, Complementary
Eukaryotic Cells
Gene Deletion
Genetic Engineering
Genome, Human
HeLa Cells
Humans
Long Interspersed Nucleotide Elements
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Polymorphism, Genetic
Recombinant Fusion Proteins
Retroelements

Source

Open in PubMed

Identifiers

PMID: 12176319
DOI: 10.1016/s0092-8674(02)00828-0

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