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Article

Genomic deletions created upon LINE-1 retrotransposition.

Cell - 9 Aug 2002

Gilbert Nicolas, Lutz-Prigge Sheila, Moran John V

Abstract excerpt

LINE-1 (L1) retrotransposition continues to impact the human genome, yet little is known about how L1 integrates into DNA. Here, we developed a plasmid-based rescue system and have used it to recover 37 new L1 retrotransposition events from cultured human cells. Sequencing of the insertions revealed the usual L1 structural hallmarks; however, in four instances, retrotransposition generated large target site...

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Identifiers

PMID: 12176319
DOI: 10.1016/s0092-8674(02)00828-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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