Article

Preventing escape and malfunction of recoded cells due to tRNA base changes

2024-07-19

Abstract excerpt

Engineering the genetic code restricts DNA transfer (cellular bioisolation) and enables new chemistries via non-standard amino acid incorporation. These distinct properties make recoded cells state-of-the-art safe technologies. However, evolutionary pressures may endanger the longevity of the recoding. Here, we reveal that recoded Escherichia coli lacking 18,214 serine codons and two tRNA Ser can express wild-ty...

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Literature Corpus work: 2eb8f7d3-a260-5472-a79d-c8cea62b668c
DOI: 10.1101/2024.07.18.604179

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