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Article

Release Factor Inhibiting Antimicrobial Peptides Improve Nonstandard Amino Acid Incorporation in Wild-type Bacterial Cells.

ACS chemical biology - 17 Jul 2020

Kuru Erkin, Määttälä Rosa-Maria, Noguera Karen, Stork Devon A, Narasimhan Kamesh, Rittichier Jonathan, Wiegand Daniel, Church George M

Abstract excerpt

We report a tunable chemical genetics approach for enhancing genetic code expansion in different wild-type bacterial strains that employ apidaecin-like, antimicrobial peptides observed to temporarily sequester and thereby inhibit Release Factor 1 (RF1). In a concentration-dependent matter, these peptides granted a conditional lambda phage resistance to a recoded Escherichia coli strain with nonessential RF1...

Topics

Amino Acids
Antimicrobial Cationic Peptides
Bacteria
Genetic Code
Mutation
Peptide Library
Peptide Termination Factors
Protein Biosynthesis
Proteins
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32603088
DOI: 10.1021/acschembio.0c00055

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