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Continuous Hypermutation and Evolution of Noncanonical Amino Acid Synthases.

ACS synthetic biology - 17 Jul 2026

Furuhata Yuichi, Rix Gordon, Almhjell Patrick J, Liu Chang C

Abstract excerpt

Genetic code expansion (GCE) enables the site-specific incorporation of noncanonical amino acids (ncAAs) into proteins but is constrained by reliance on exogenously supplied chiral ncAAs. Achieving intracellular ncAA biosynthesis would enable more scalable and cost-effective GCE. Here, we report the continuous hypermutation and evolution of amino acid synthases that produce high levels of ncAAs inside yeast, thus...

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PMID: 42345497
DOI: 10.1021/acssynbio.6c00338

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