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Article

Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut.

ACS synthetic biology - 19 Sept 2025

Foo Gary W, Uruthirapathy Aathavan S, Zhang Claire Q, Batko Izabela Z, Heinrichs David E, Edgell David R

Abstract excerpt

Imbalances in the mammalian gut are associated with acute and chronic conditions, and using engineered probiotic strains to deliver synthetic constructs to treat them is a promising strategy. However, high rates of mutational escape and genetic instability in vivo limit the effectiveness of biocontainment circuits needed for safe and effective use. Here, we describe STALEMATE (Sequence enTAngLEd Multi lAyered...

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PMID: 40914949
DOI: 10.1021/acssynbio.5c00412
PMCID: PMC12455656

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