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Article

Adaptive evolution of genomically recoded Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2018

Wannier Timothy M, Kunjapur Aditya M, Rice Daniel P, McDonald Michael J, Desai Michael M, Church George M

Abstract excerpt

Efforts are underway to construct several recoded genomes anticipated to exhibit multivirus resistance, enhanced nonstandard amino acid (nsAA) incorporation, and capability for synthetic biocontainment. Although our laboratory pioneered the first genomically recoded organism (Escherichia coli strain C321.∆A), its fitness is far lower than that of its nonrecoded ancestor, particularly in defined media. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29440500
DOI: 10.1073/pnas.1715530115
PMCID: PMC5866557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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