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Evolving Orthogonal Suppressor tRNAs To Incorporate Modified Amino Acids.

ACS synthetic biology - 20 Jan 2017

Maranhao Andre C, Ellington Andrew D

Abstract excerpt

There have been considerable advancements in the incorporation of noncanonical amino acids (ncAA) into proteins over the last two decades. The most widely used method for site-specific incorporation of noncanonical amino acids, amber stop codon suppression, typically employs an orthogonal translation system (OTS) consisting of a heterologous aminoacyl-tRNA synthetase:tRNA pair that can potentially expand an...

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PMID: 27600875
DOI: 10.1021/acssynbio.6b00145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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