Article

Cas9-Assisted Biological Containment of a Genetically Engineered Human Commensal Bacterium and Genetic Elements

2021-11-03

Abstract excerpt

<h4>ABSTRACT</h4> Sophisticated gene circuits built by synthetic biology can enable bacteria to sense their environment and respond predictably. Biosensing bacteria can potentially probe the human gut microbiome to prevent, diagnose, or treat disease. To provide robust biocontainment for engineered bacteria, we devised a Cas9-assisted auxotrophic biocontainment system combining thymidine auxotrophy, an Engineered...

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Literature Corpus work: 09bc0d8c-03b3-56a9-bdcb-bc76648e24af
DOI: 10.1101/2021.11.03.467106

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