Article

One-for-all gene inactivation via PAM-independent base editing in bacteria

2024-06-18

Abstract excerpt

Base editing is preferable for bacterial gene inactivation without generating double strand breaks, requiring homology recombination or highly efficient DNA delivery capability. However, the potential of base editing is limited by the adjoined dependence on the editing window and protospacer adjacent motif (PAM). Herein, we report an unconstrained base editing system to enable the inactivation of any genes of inte...

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Identifiers and source

Literature Corpus work: 038ac75d-1932-54f9-9ac3-0bf215a6353d
DOI: 10.1101/2024.06.17.599441

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