Article

Vulnerability in the breadth evolution of an influenza broadly neutralizing antibody

2025-11-04

Abstract excerpt

<h4>ABSTRACT</h4> The highly conserved influenza hemagglutinin (HA) stem domain is a major target for broadly neutralizing antibodies (bnAbs). However, despite being discovered more than a decade ago, the IGHV1-69-encoded CR9114 remains the only HA stem bnAb that cross-reacts with both influenza A and B viruses. To investigate the constraints on the breadth evolution of CR9114, this study performs four deep mutat...

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Literature Corpus work: 2ea5daae-a9a9-56d4-8290-05a9ce0609da
DOI: 10.1101/2025.11.03.686356

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