Article

Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies

2021-05-25

Abstract excerpt

Over the past two decades, several broadly neutralizing antibodies (bnAbs) that confer protection against diverse influenza strains have been isolated 1,2 . Structural and biochemical characterization of these bnAbs has provided molecular insight into how they bind distinct antigens 1 . However, our understanding of the evolutionary pathways leading to bnAbs, and thus how best to elicit them, remains limited. He...

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Literature Corpus work: ee0dff0b-2fbc-563b-adc0-398fd1c61ed0
DOI: 10.1101/2021.05.25.445596

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