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In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

15 May 2017

Abstract excerpt

The relatively recent discovery and characterization of human broadly neutralizing antibodies (bnAbs) against influenza virus provide valuable insights into antiviral and vaccine development. However, the factors that influence the evolution of high-affinity bnAbs remain elusive. We therefore explore the functional sequence space of bnAb C05, which targets the receptor-binding site (RBS) of influenza...

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PMID: 28504265
DOI: 10.1038/ncomms15371

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