Article
Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies.
eLife - 7 Sept 2021
Phillips Angela M, Lawrence Katherine R, Moulana Alief, Dupic Thomas, Chang Jeffrey, Johnson Milo S, Cvijovic Ivana, Mora Thierry, Walczak Aleksandra M, Desai Michael M
Abstract excerpt
Over the past two decades, several broadly neutralizing antibodies (bnAbs) that confer protection against diverse influenza strains have been isolated. Structural and biochemical characterization of these bnAbs has provided molecular insight into how they bind distinct antigens. However, our understanding of the evolutionary pathways leading to bnAbs, and thus how best to elicit them, remains limited. Here, we...
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