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Article

Convergent Evolution in Breadth of Two VH6-1-Encoded Influenza Antibody Clonotypes from a Single Donor

2 Jul 2020

Abstract excerpt

Understanding how broadly neutralizing antibodies (bnAbs) to influenza hemagglutinin (HA) naturally develop in humans is critical to the design of universal influenza vaccines. Several classes of bnAbs directed to the conserved HA stem were found in multiple individuals, including one encoded by heavy-chain variable domain V H 6-1. We describe two genetically similar V H 6-1 bnAb clonotypes from the same...

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Influenza Virus Research Studies
Monoclonal and Polyclonal Antibodies Research
RNA and protein synthesis mechanisms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32619441
DOI: 10.1016/j.chom.2020.06.003

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