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A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve

13 Sept 2016

Abstract excerpt

Understanding the natural evolution and structural changes involved in broadly neutralizing antibody (bnAb) development holds great promise for improving the design of prophylactic influenza vaccines. Here we report an haemagglutinin (HA) stem-directed bnAb, 3I14, isolated from human memory B cells, that utilizes a heavy chain encoded by the IGHV3-30 germline gene. MAb 3I14 binds and neutralizes groups 1 and 2...

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Immune Cell Function and Interaction
Influenza Virus Research Studies
T-cell and B-cell Immunology

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27619409
DOI: 10.1038/ncomms12780

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