Article
Rapid development of broadly influenza neutralizing antibodies through redundant mutations.
Nature - 18 Dec 2014
Pappas Leontios, Foglierini Mathilde, Piccoli Luca, Kallewaard Nicole L, Turrini Filippo, Silacci Chiara, Fernandez-Rodriguez Blanca, Agatic Gloria, Giacchetto-Sasselli Isabella, Pellicciotta Gabriele, Sallusto Federica, Zhu Qing, Vicenzi Elisa, Corti Davide, Lanzavecchia Antonio
Abstract excerpt
The neutralizing antibody response to influenza virus is dominated by antibodies that bind to the globular head of haemagglutinin, which undergoes a continuous antigenic drift, necessitating the re-formulation of influenza vaccines on an annual basis. Recently, several laboratories have described a new class of rare influenza-neutralizing antibodies that target a conserved site in the haemagglutinin stem. Most of...
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