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Article

Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem.

Cell reports - 19 Sept 2017

Lang Shanshan, Xie Jia, Zhu Xueyong, Wu Nicholas C, Lerner Richard A, Wilson Ian A

Abstract excerpt

Antibodies that target both group 1 and group 2 influenza A viruses are valuable for therapeutic and vaccine development, but only a few have been reported to date. Here, we describe a new VH1-69 antibody 27F3 that broadly recognizes heterosubtypic hemagglutinins (HAs) from both group 1 and group 2 influenza A viruses. Structural characterization of 27F3 Fab with A/California/04/2009 (H1N1) hemagglutinin...

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Antibodies, Neutralizing
Hemagglutinin Glycoproteins, Influenza Virus
Immunoglobulin Fab Fragments
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Influenza A virus

Influenza, Human

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Identifiers

PMID: 28930686
DOI: 10.1016/j.celrep.2017.08.084
PMCID: PMC5679313

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