Article

Influenza H3 and H1 hemagglutinins have different genetic barriers for resistance to broadly neutralizing stem antibodies

2019-12-30

Abstract excerpt

<h4>ABSTRACT</h4> In the past decade, the discovery and characterization of broadly neutralizing antibodies (bnAbs) to the highly conserved stem region of influenza hemagglutinin (HA) have provided valuable insights for development of a universal influenza vaccine. However, the genetic barrier for resistance to stem bnAbs has not been thoroughly evaluated. Here, we performed a series of deep mutational scanning e...

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Literature Corpus work: 09541e84-7854-5dc7-b1f4-38abad713e5f
DOI: 10.1101/2019.12.30.891135

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