Article

The influenza hemagglutinin stem antibody CR9114: Evidence for a narrow evolutionary path towards universal protection

2022-11-02

Abstract excerpt

Human monoclonal antibodies (hmAbs) that protect against all influenza A and B strains are considered the road to universal influenza vaccines. Based on publicly-available data, we analyze the mechanistic and structural basis of pan-influenza protection by CR9114, a hemagglutinin (HA) stem-reactive antibody that protects against influenza subtypes from groups A1, A2, and B. The mechanistic basis of CR9114’s univer...

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Literature Corpus work: 48552076-9c9f-57b9-a692-2dbc3950c220
DOI: 10.3389/fviro.2022.1049134

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