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Article

Overexpressed somatic alleles are enriched in functional elements in Breast Cancer.

Scientific reports - 15 Aug 2017

Restrepo Paula, Movassagh Mercedeh, Alomran Nawaf, Miller Christian, Li Muzi, Trenkov Chris, Manchev Yulian, Bahl Sonali, Warnken Stephanie, Spurr Liam, Apanasovich Tatiyana, Crandall Keith, Edwards Nathan, Horvath Anelia

Abstract excerpt

Asymmetric allele content in the transcriptome can be indicative of functional and selective features of the underlying genetic variants. Yet, imbalanced alleles, especially from diploid genome regions, are poorly explored in cancer. Here we systematically quantify and integrate the variant allele fraction from corresponding RNA and DNA sequence data from patients with breast cancer acquired through The Cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28811643
DOI: 10.1038/s41598-017-08416-w
PMCID: PMC5557904

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